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TIDAL: Target-Induced Droplet Assembly of Ligands

Name: TIDAL: Target-Induced Droplet Assembly of Ligands
Creator: ENERGY, DEPARTMENT OF
Published: 2026-09-08T00:00:00+00:00
Keywords: CSO

ENERGY, DEPARTMENT OFENERGY, DEPARTMENT OF.ENERGY, DEPARTMENT OF.TRIAD - DOE CONTRACTOR

AI Overview

TIDAL technology platform developed by Los Alamos National Laboratory transforms nanobodies into programmable protein-only materials using liquid-liquid phase separation for protein purification, drug delivery, and therapeutic diagnostics applications.

This summary is AI-generated from the official solicitation.

Key Details

Agency

ENERGY, DEPARTMENT OF

Funding Amount

—

Release Date

September 8, 2026

Due Date

December 9, 2026

Official Description

Developed by Los Alamos National Laboratory, TIDAL (Target-Induced Droplet Assembly of Ligands) transforms the small antibody fragments known as nanobodies into a programmable, protein-only material that organizes itself on demand. By harnessing a natural process called liquid-liquid phase separation, TIDAL lets these binders gather into dense, dynamic droplets precisely when they encounter their intended target, giving developers a single platform that can purify proteins without costly resins,...

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Change History

Opportunity AddedSep 8, 2026 at 9:04 PM