This solicitation closed on May 13, 2026

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CBD254-010CancelledSBIR

Shelf-Stable Nucleic Acid Synthesis Reagents for Field-Deployable Diagnostics

Department of DefenseCBD

AI Overview

Mobile diagnostic card interface for rapidly synthesizing stable nucleic acid reagents in extreme field conditions, enabling point-of-need test development without cold storage requirements and supporting molecular assay generation across challenging environmental scenarios.

This summary is AI-generated from the official solicitation.

Key Details

Agency
Department of Defense
Funding Amount
Release Date
November 18, 2025
Due Date
May 13, 2026 (Closed)
Phase I Award
$209,575.00

Official Description

The Chemical and Biological Defense Program (CBDP) faces a critical challenge: the need for rapid, deployable diagnostic capabilities in far forward or expeditionary environments. Maintaining the health and readiness of the total force hinges on the ability to rapidly develop and deploy diagnostic assays in response to emerging threats and infectious diseases. However, current technologies present significant limitations. Existing nucleic acid synthesizers rely on reagents that demand cold chain...

View on official source

Change History

Opportunity RemovedMay 13, 2026 at 4:58 PM

Shelf-Stable Nucleic Acid Synthesis Reagents for Field-Deployable Diagnostics

Opportunity CBD254-010 no longer available

Status ChangedMay 13, 2026 at 1:10 AM

Shelf-Stable Nucleic Acid Synthesis Reagents for Field-Deployable Diagnostics

Status changed from Open to Open

Q&A UpdatedMay 1, 2026 at 12:33 PM

Shelf-Stable Nucleic Acid Synthesis Reagents for Field-Deployable Diagnostics

**No substantive changes detected.** The Previous and Updated Q&A sections are identical. All four Q&As and their answers remain unchanged. No new questions were added, no pending responses were resolved, and no answers were updated or clarified.

Q&A UpdatedApr 28, 2026 at 3:58 PM

Shelf-Stable Nucleic Acid Synthesis Reagents for Field-Deployable Diagnostics

**Q&A Changes:** Added 1 new question (Q1) clarifying whether applicants can stabilize existing commercial reagents or must develop novel reagents from scratch. The answer emphasizes that innovation must be in novel chemistry and formulation of reagents themselves, not just stabilization of existing products.

Q&A UpdatedApr 23, 2026 at 11:34 AM

Shelf-Stable Nucleic Acid Synthesis Reagents for Field-Deployable Diagnostics

No changes detected. The previous and updated Q&A sections are identical. All three Q&As and their answers remain the same.

Q&A UpdatedApr 16, 2026 at 1:01 AM

Shelf-Stable Nucleic Acid Synthesis Reagents for Field-Deployable Diagnostics

# Q&A Changes Summary **New Answer Added:** Q1 clarified that the program focuses on shelf-stable reagent chemistry/formulation development, not specific synthesis platforms or nucleic acid types. Innovation must be in reagent chemistry applicable to large ssDNA synthesis.

Status ChangedApr 14, 2026 at 11:32 AM

Shelf-Stable Nucleic Acid Synthesis Reagents for Field-Deployable Diagnostics

Status changed from Pre-Release to Open

Date ChangedMar 19, 2026 at 12:15 PM

Shelf-Stable Nucleic Acid Synthesis Reagents for Field-Deployable Diagnostics

Close Date changed from 2026-03-04 to 2026-04-29

Date ChangedMar 19, 2026 at 12:15 PM

Shelf-Stable Nucleic Acid Synthesis Reagents for Field-Deployable Diagnostics

Open Date changed from 2026-02-11 to 2026-04-01

Date ChangedFeb 3, 2026 at 12:24 AM

Shelf-Stable Nucleic Acid Synthesis Reagents for Field-Deployable Diagnostics

Close Date changed from 2026-02-25 to 2026-03-04

Date ChangedFeb 3, 2026 at 12:24 AM

Shelf-Stable Nucleic Acid Synthesis Reagents for Field-Deployable Diagnostics

Open Date changed from 2026-02-04 to 2026-02-11

Date ChangedJan 20, 2026 at 4:10 PM

Shelf-Stable Nucleic Acid Synthesis Reagents for Field-Deployable Diagnostics

Close Date changed from 2026-02-11 to 2026-02-25

Date ChangedJan 20, 2026 at 4:10 PM

Shelf-Stable Nucleic Acid Synthesis Reagents for Field-Deployable Diagnostics

Open Date changed from 2026-01-21 to 2026-02-04

Date ChangedJan 12, 2026 at 8:06 PM

Shelf-Stable Nucleic Acid Synthesis Reagents for Field-Deployable Diagnostics

Close Date changed from 2026-02-04 to 2026-02-11

Date ChangedJan 12, 2026 at 8:06 PM

Shelf-Stable Nucleic Acid Synthesis Reagents for Field-Deployable Diagnostics

Open Date changed from 2026-01-14 to 2026-01-21

Q&A UpdatedJan 8, 2026 at 1:53 PM

Shelf-Stable Nucleic Acid Synthesis Reagents for Field-Deployable Diagnostics

Q&A section updated

Description ChangedJan 8, 2026 at 1:53 PM

Shelf-Stable Nucleic Acid Synthesis Reagents for Field-Deployable Diagnostics

Content updated: description, objective, phase_1_description, phase_2_description, phase_3_description

Q&A UpdatedJan 7, 2026 at 10:05 PM

Shelf-Stable Nucleic Acid Synthesis Reagents for Field-Deployable Diagnostics

Q&A section updated

Description ChangedJan 7, 2026 at 10:05 PM

Shelf-Stable Nucleic Acid Synthesis Reagents for Field-Deployable Diagnostics

Content updated: description, objective, phase_1_description, phase_2_description, phase_3_description

Q&A UpdatedJan 7, 2026 at 12:17 AM

Shelf-Stable Nucleic Acid Synthesis Reagents for Field-Deployable Diagnostics

Q&A section updated

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