This solicitation closed on May 13, 2026
View current Department of Defense opportunities →Microphysiological systems to Assess Pretreatment Immunogenicity and Efficacy (MAGPIE)
AI Overview
Microphysiological systems (iMPS) offer a breakthrough in vaccine development by modeling human immune responses in vitro, bridging the gap between preclinical studies and clinical trials. By accurately predicting vaccine immunogenicity, efficacy, and potential side effects, iMPS can accelerate medical countermeasure discovery for emerging threats to military personnel.
This summary is AI-generated from the official solicitation.
Key Details
Official Description
The Defense Threat Reduction Agency (DTRA) Research and Development Chemical and Biological Technologies Directorate Medical division in support of the Joint Science and Technology Office (JSTO) is charged with addressing the potential threat to the armed services posed by a wide range of pathogenic and toxic agents. In support of warfighter readiness, vaccines build a defense against known and future threats. However, the development of vaccines is stymied by traditional in vitro or in vivo mod...
Change History
Microphysiological systems to Assess Pretreatment Immunogenicity and Efficacy (MAGPIE)
Opportunity CBD254-012 no longer available
Microphysiological systems to Assess Pretreatment Immunogenicity and Efficacy (MAGPIE)
Status changed from Open to Open
Microphysiological systems to Assess Pretreatment Immunogenicity and Efficacy (MAGPIE)
No changes detected. The previous and updated Q&A sections are identical. All three questions and answers remain unchanged.
Microphysiological systems to Assess Pretreatment Immunogenicity and Efficacy (MAGPIE)
Status changed from Pre-Release to Open
Microphysiological systems to Assess Pretreatment Immunogenicity and Efficacy (MAGPIE)
Q&A section updated
Microphysiological systems to Assess Pretreatment Immunogenicity and Efficacy (MAGPIE)
Close Date changed from 2026-03-04 to 2026-04-29
Microphysiological systems to Assess Pretreatment Immunogenicity and Efficacy (MAGPIE)
Open Date changed from 2026-02-11 to 2026-04-01
Microphysiological systems to Assess Pretreatment Immunogenicity and Efficacy (MAGPIE)
Close Date changed from 2026-02-25 to 2026-03-04
Microphysiological systems to Assess Pretreatment Immunogenicity and Efficacy (MAGPIE)
Open Date changed from 2026-02-04 to 2026-02-11
Microphysiological systems to Assess Pretreatment Immunogenicity and Efficacy (MAGPIE)
Close Date changed from 2026-02-11 to 2026-02-25
Microphysiological systems to Assess Pretreatment Immunogenicity and Efficacy (MAGPIE)
Open Date changed from 2026-01-21 to 2026-02-04
Microphysiological systems to Assess Pretreatment Immunogenicity and Efficacy (MAGPIE)
Close Date changed from 2026-02-04 to 2026-02-11
Microphysiological systems to Assess Pretreatment Immunogenicity and Efficacy (MAGPIE)
Open Date changed from 2026-01-14 to 2026-01-21
Microphysiological systems to Assess Pretreatment Immunogenicity and Efficacy (MAGPIE)
Q&A section updated
Microphysiological systems to Assess Pretreatment Immunogenicity and Efficacy (MAGPIE)
Content updated: description, objective, phase_1_description, phase_2_description, phase_3_description
Microphysiological systems to Assess Pretreatment Immunogenicity and Efficacy (MAGPIE)
Q&A section updated
Microphysiological systems to Assess Pretreatment Immunogenicity and Efficacy (MAGPIE)
Content updated: description, objective, phase_1_description, phase_2_description, phase_3_description
Microphysiological systems to Assess Pretreatment Immunogenicity and Efficacy (MAGPIE)
Q&A section updated
Microphysiological systems to Assess Pretreatment Immunogenicity and Efficacy (MAGPIE)
Content updated: description, objective, phase_1_description, phase_2_description, phase_3_description
Microphysiological systems to Assess Pretreatment Immunogenicity and Efficacy (MAGPIE)
Q&A section updated
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