Department of Defense

Fundamental medical research addressing congressionally prioritized disease areas. Supports use-inspired basic research with preliminary data to advance patient care and quality of life outcomes.

High-risk, high-reward medical research discovery projects addressing critical DoD health challenges. Pioneering studies generating preliminary data to launch future scientific investigation and product development.

AFGSC seeks prototype modular, open-architecture pod systems for the B-52 that integrate sensing, electronic warfare, and communications capabilities. The solution enables rapid fielding of advanced mission systems without lengthy aircraft modifications, enhancing survivability in contested environments.

Develop a secure, AI-assisted tool that helps Army staff write clearer, more concise briefings aligned with military doctrine. The prototype aims to reduce preparation time, improve decision-making speed, and standardize communication quality across operational commands.

Prototype an integrated data-driven facility management and environmental compliance platform for Picatinny Arsenal. This real-property decision-support system will modernize legacy contract structures, accelerate facility readiness, and validate cost-efficient acquisition strategies under live operational conditions.

Translate proven medical research into clinical products—drugs, devices, or decision-support tools—addressing military health needs. Support moves promising preclinical work through final development toward regulatory approval or clinical practice.

DoD seeks clinical research combining occupational science, psychology, and implementation science to address congressionally directed health topics. Projects must include patient advocates and demonstrate solutions to real-world health challenges.

DoD seeks applied medical research that translates basic science into near-term clinical solutions for military health problems. Fund up to $3.6M over 4 years for use-inspired research addressing congressionally directed priority topics.

This DoD grant funds exploratory research into tuberous sclerosis complex treatments, welcoming high-risk, innovative concepts without requiring preliminary data. It supports early-stage hypothesis development to advance breakthrough therapeutic approaches.

This DoD program funds innovative research into tuberous sclerosis complex (TSC) to drive critical discoveries and improve patient care. It welcomes both established researchers and investigators new to the TSC field, with separate competitive tracks.

This DoD award supports clinical translational research to advance tuberous sclerosis complex diagnosis, prognosis, and treatments from promising preclinical findings toward real-world clinical application. Multi-PI teams can collaborate on moving TSC research closer to patient care.

DoD seeks basic research proposals from HBCUs and TCUs in critical technology areas including AI, biomanufacturing, quantum computing, and hypersonics. Projects must advance fundamental knowledge while building institutional research capacity and developing STEM talent for national defense.

This DoD program funds clinical trials for multiple sclerosis treatments, from early-stage proof-of-concept to phase 2 studies. It supports testing of new drugs, biologics, devices, and emerging technologies to improve MS management.

Support innovative, high-risk MS research concepts at early exploration stages through hypothesis development. This award funds groundbreaking studies that establish foundations for future scientific investigation, with no preliminary data required.

Support early-stage researchers investigating Multiple Sclerosis through independent, mentor-guided projects. This award develops the next generation of MS researchers by funding novel research questions and advancing scientific careers in neuroimmunology.

Support rigorous, investigator-initiated research projects advancing Multiple Sclerosis understanding and patient outcomes. Funding available for laboratory, clinical, and population-based studies with preliminary data, including dedicated tracks for early-career investigators.

DoD seeks novel research on post-traumatic epilepsy and related conditions to improve outcomes for Service Members and Veterans. Awards support creative new research directions that challenge existing paradigms, open to investigators at all career levels.

This DoD program funds collaborative research partnerships tackling post-traumatic epilepsy (PTE), requiring at least two investigators with complementary expertise to synergistically address critical scientific questions that individual efforts couldn't achieve.

This DoD award funds basic, translational, and clinical research to understand post-traumatic epilepsy by repurposing existing research cohorts, tools, or resources. It accelerates discovery by applying established resources to a new medical challenge.

DoD seeks to develop new investigators in post-traumatic epilepsy research through a virtual research center offering mentoring, networking, and collaboration. The program aims to expand the PTE research field by supporting faculty with career guidance and peer support.

DoD seeks experienced leadership to direct a virtual post-traumatic epilepsy research center, mentoring new investigators and building a collaborative network to advance PTE research quality and expand the field.

The Air Force seeks low-cost kinetic defeat systems to neutralize small unmanned aircraft threats at under $6,000 per engagement. Solutions must feature autonomous guidance, GPS-denied operation, and multi-target capability to address the cost-inefficiency of current interceptors against commercial drone swarms.

This RFP seeks innovative commercial sensing and analytics solutions to deliver real-time tactical surveillance, reconnaissance, and tracking capabilities for military operators. The effort aims to close gaps in operational responsiveness by rapidly integrating commercially available space and ground-based insights with advanced data processing and fusion technologies.

This RFP seeks a software-defined flight antenna enabling secure, high-speed communications between interceptor missiles in contested environments. The system must support multiple simultaneous beams, frequency hopping, and operate across S+ to Ka bands while fitting within a 10-inch diameter constraint.

This RFP seeks AI-enabled autonomy software that generates game-theoretically optimized courses of action for coordinating UAS swarms in contested, degraded environments. The system must scale to 200+ aircraft, incorporate adversarial reasoning, and support decentralized decision-making for maritime and air defense operations.