High-risk, high-reward medical research discovery projects addressing critical DoD health challenges. Pioneering studies generating preliminary data to launch future scientific investigation and product development.
Support early-career clinical trialists developing new ovarian cancer treatments through intensive mentoring, networking, and conducting translational research and early-phase clinical trials.
DoD funds breakthrough breast cancer research advancing toward clinical trials, requiring multidisciplinary teams with consumer advocates. This Level 4 award targets high-impact discoveries ready for human testing and clinical application.
This award funds clinical trials for new ovarian cancer treatments, from early proof-of-concept studies through large-scale efficacy trials. It supports evaluation of drugs, biologics, devices, and emerging technologies to improve patient outcomes.
Support high-impact investigator-initiated research addressing ovarian cancer through basic laboratory to translational studies. Projects must demonstrate strong scientific rationale with preliminary data and potential to advance patient care.
The Army seeks research ideas to advance understanding and countermeasures for tick-borne diseases affecting military readiness. This program supports early-stage scientific investigations to develop novel prevention, diagnosis, or treatment solutions.
This DoD funding supports high-risk, hypothesis-driven research to discover new ALS drugs and therapies. Applications emphasizing novel approaches can succeed without preliminary data, enabling bold therapeutic innovation.
This DoD award supports clinical translational research to advance tuberous sclerosis complex diagnosis, prognosis, and treatments from promising preclinical findings toward real-world clinical application. Multi-PI teams can collaborate on moving TSC research closer to patient care.
This DoD program funds exploratory pancreatic cancer research with a patient-centered focus to develop innovative concepts and generate preliminary data for future clinical applications. Supported research should advance quality of life outcomes through robust studies that avoid preclinical animal work.
DoD seeks clinical trial research to advance treatment and management of military-relevant diseases. This peer-reviewed program funds trials from early-phase (Phase 0/1) through large-scale Phase 3 studies, with optional planning support for regulatory preparation.
The Army seeks innovative research on military burn treatment and prevention through discovery-phase awards. This funding targets novel solutions to improve clinical outcomes for service members with severe thermal injuries.
DoD seeks clinical research combining occupational science, psychology, and implementation science to address congressionally directed health topics. Projects must include patient advocates and demonstrate solutions to real-world health challenges.
Develop civilian nuclear infrastructure cooperation programs with Türkiye to advance nonproliferation security and safety standards. This initiative counters proliferation risks from non-U.S. reactor selection and foreign supply chains through targeted technical assistance.
This DoD program funds innovative research into tuberous sclerosis complex (TSC) to drive critical discoveries and improve patient care. It welcomes both established researchers and investigators new to the TSC field, with separate competitive tracks.
This DoD grant funds exploratory research into tuberous sclerosis complex treatments, welcoming high-risk, innovative concepts without requiring preliminary data. It supports early-stage hypothesis development to advance breakthrough therapeutic approaches.
This Army Medical Research Acquisition Activity award supports mentored clinical research in vision-related medical challenges. It aims to develop clinical solutions and advance vision care capabilities through structured mentorship and research training.
This DoD award funds multidisciplinary, multi-institutional consortia addressing transformative breast cancer research challenges. Led by up to five PIs and consumer advocates, projects must tackle major problems requiring collaborative breakthroughs that single investigators cannot achieve.
Army seeks investigator-initiated research proposals addressing vision science and ocular performance challenges. Support ranges from basic science through applied research to advance soldier visual capabilities and medical treatments.
Develop ALS therapeutics from preclinical validation through FDA IND-enabling studies. This award accelerates drug candidates toward clinical testing while requiring parallel development of mechanism-specific biomarkers for improved patient selection and trial design.
Develop and test broadly applicable clinical technologies addressing urgent military health needs through translational research and early-phase clinical trials. Multi-PI teams will advance platform products that benefit Service Members, Veterans, and their families.
This DoD funding supports translational lung cancer research converting promising discoveries into clinical applications. Applicants can pursue advanced preclinical studies or pilot clinical trials addressing priority research areas.
The Army seeks translational research advancing vision science and optical technologies for military applications. This opportunity funds development of novel vision-related capabilities to bridge fundamental research and field-deployable solutions.
Support clinical trials evaluating new treatments, devices, and approaches for autism management. Awards fund proof-of-concept through large-scale efficacy studies, with funding incentives for early-career researchers partnering with experienced mentors.
Supports early-stage, high-risk lung cancer research with potential for breakthrough discoveries. Designed for conceptually innovative projects, including a dedicated track for new faculty investigators seeking transformative advances.
This grant program funds digital equity initiatives for Indian Tribes, Alaska Native entities, and Native Hawaiian organizations. It supports capacity building and competitive projects to expand broadband access and digital skills in underserved Native communities.